It's always nice to see something new and different in video games, something that doesn't fall neatly into an established genre. As the industry balloons to the size of Hollywood, and only "safe bets" are backed, indie and homebrew games have become the outlet for innovation.
Which brings us to One Chance by AwkwardSilenceGames. In One Chance you play a cancer researcher who has unwittingly insured the destruction of the human race. You are faced with various choices about how you deal with humanity's final days and as the game states, you only have one chance... There are no saves, no retries. You live with the consequences of your actions which makes for a surprisingly compelling experience.